How NovuBrain+ Compares

NovuBrain+ contains three compounds that are also sold as single-ingredient bottles — so the comparison is not this or that, but a known amount against one routine.

By Chris Andrade·Updated September 2026·6 min read

Quick answer

NovuBrain+ contains phosphatidylserine, DHA omega-3 and huperzine A, each also sold on its own. Bought separately, you can match the amounts the research used, such as 100 to 300 mg of phosphatidylserine. Bought together, you get all three plus bacopa in two caffeine-free capsules and a one-time purchase, at amounts the sales page does not publish.

Most comparisons in this category set one formula against another. This one is more useful, because of a fact from the review page: NovuBrain+ contains three compounds that are also sold as single-ingredient bottles — phosphatidylserine, fish oil or DHA, and huperzine A.

If you have already bought one of those, you are exactly who this page is for. The question is not which is stronger. It is a real trade-off between two ways of getting the same compounds, and the honest answer depends on how you actually take supplements.

The Trade-Off, Stated Plainly

Buy them separately and you control the amounts. You can pick a phosphatidylserine capsule at 100 or 300 mg and know it sits inside the range the trials used. You can choose a fish oil that states its DHA on the label. You know exactly what you are taking, and in what quantity.

Buy them together and you get one bottle, one routine — two capsules with breakfast — and one refund window. You also get bacopa, L-glutamine, DMAE and vitamin B12 alongside, without adding another bottle. What you give up is the arithmetic: the sales page publishes no amounts, so you cannot line NovuBrain+ up against any trial.

Both are reasonable. Neither is the clever choice. Which suits you comes down to a question almost nobody asks honestly: are you more likely to keep up with three bottles, or with one? The evidence in this category needs weeks to months of consistency, and a routine you keep beats a better-specified one you stop.

What The Research Used

Before the table, the numbers that matter, because they are what a single-ingredient bottle lets you match.

Comparison of the amounts used in published human research with what the NovuBrain+ sales page publishes. Bacopa trials used 300 mg a day for 8 to 12 weeks. Phosphatidylserine trials used 100 to 300 mg a day for 6 weeks to 6 months. The largest omega-3 trial in older adults used 840 mg of EPA and DHA a day for 2 to 3 years. Huperzine A amounts vary across trials. For all four, the amount in NovuBrain+ is not stated. — The amounts the published human research used, next to what the NovuBrain+ sales page publishes.

The Comparison

Read across a row rather than down a column. There is no score here and no order of merit — each cell describes what that option covers.

Criteria	NovuBrain+	Phosphatidylserine on its own	Fish oil or DHA on its own	Huperzine A on its own

What you get	Seven compounds, including all three of the others	One compound	Omega-3 fatty acids, usually DHA with EPA	One compound
Amount printed	Not stated on the sales page	Yes, as standard	Yes, as standard	Yes, as standard
What the research used	Cannot be checked from the sales page	100 to 300 mg a day, 6 weeks to 6 months	840 mg EPA and DHA a day, 2 to 3 years, in the largest trial in older adults	Varies across trials
Strength of the evidence	Inherited from its ingredients, not tested as a formula	Modest, in older adults with cognitive decline	Mixed, and it depends on who was studied	An active compound; reviewers note the trials are of low quality
Daily routine	Two capsules with breakfast	Usually one or more capsules	Usually one or more softgels	Usually one capsule
Caffeine	None, by the maker’s description	None	None	None
How it is sold	One-time packs, 60-day guarantee	Varies by seller	Varies by seller	Varies by seller
Where to buy	Official site →	Sold everywhere	Sold everywhere	Sold everywhere

Prices are the maker's list price at the time of writing and change without notice. Every link goes through our own redirect and lands on the maker's official site.

If you take a prescription, ask your prescriber before combining any of these with it. Huperzine A and fish oil are the two worth naming specifically, and that applies whether you take them in NovuBrain+ or separately.

What NovuBrain+ Brings That Three Bottles Do Not

One routine instead of three. Two capsules with breakfast replaces three separate bottles, three sets of instructions and three chances to stop halfway.
Bacopa alongside. The best-studied memory botanical in this category comes in the same capsules, paired with huperzine A, at no extra decision on your part.
No caffeine. Nothing in the formula is a stimulant, by the maker’s description, so it adds nothing to an afternoon or an evening that is already restless.
One purchase, one guarantee. A one-time pack with a 60-day empty-bottle guarantee, instead of three sellers with three different return policies.

If the combination is what you want, see NovuBrain+

Which One Fits Which Situation

If you want to match the research exactly, buy the single ingredients. That is the only route where you can verify the amount you take.
If you have already abandoned a supplement halfway, one bottle and one routine is the honest choice. It is built for the way people actually behave.
If you only want to try one compound to see how you respond, a single ingredient tells you something a combination never can — which of them did anything.
If you want the membrane pair and the memory pair together, without caffeine and without a subscription, that is the specific thing NovuBrain+ is arranged to offer.

See NovuBrain+ on the official site

Frequently asked

If NovuBrain+ contains phosphatidylserine and DHA, why not just buy those separately?

That is the real trade-off. Buying them separately lets you match the amounts the research used — phosphatidylserine trials used 100 to 300 mg a day. Buying them in NovuBrain+ gives you both, plus bacopa and huperzine A, in two capsules a day, at amounts the sales page does not publish. Which matters more depends on whether you would rather check the arithmetic or keep one routine.

Is a combination better than a single ingredient?

That is not established, here or generally. There is no published trial on this combination, so the honest position is that a blend is a different design rather than a stronger one. What it does give you is one routine instead of several, and adherence is the quiet variable in a category where the evidence needs weeks to months.

Is huperzine A safe to take on its own?

It is a pharmacologically active compound: it slows the breakdown of acetylcholine, the same way some prescription memory medicines work. A 2025 review describes it as generally well tolerated at usual amounts, reports nausea, diarrhea and muscle cramps when too much is taken, and advises using it with professional guidance. That applies whether you take it on its own or in a blend.

Can I take any of these with prescription medication?

Ask your prescriber before combining. Huperzine A is the one to name first: Memorial Sloan Kettering lists interactions with donepezil, galantamine and rivastigmine, with beta-blockers and calcium channel blockers, and with medicines that block dopamine. Fish oil and DHA are worth raising if you take warfarin or another blood thinner. That applies whether you take them in NovuBrain+ or separately.

References

Effect of phosphatidylserine on cognitive function in the elderly: a systematic review and meta-analysis — 2022
Marine n-3 fatty acids and cognitive change among older adults in the VITAL randomized trial — Alzheimer’s & Dementia: Translational Research & Clinical Interventions — 2022
Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild cognitive impairment: a meta-analysis of randomized controlled trials — European Journal of Nutrition — 2024
Huperzia serrata — About Herbs, Memorial Sloan Kettering Cancer Center — 2022
Huperzine A: a natural acetylcholinesterase inhibitor with multifunctional neuroprotective effects — Beni-Suef University Journal of Basic and Applied Sciences — 2025

About the author

Chris Andrade — writes for The Supplement Hub, covering supplement formulas across health categories with a focus on what a product label actually tells the reader. Her work centers on three questions: which ingredients and amounts a label discloses, which ones it leaves out, and how a formula fits alongside the medications and supplements someone is already taking. Every review she writes is checked by The Supplement Hub editorial team against the standards published in our editorial policy before it goes live.

Disclosure

All content is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Each product covered is a dietary supplement, not a prescription drug, and statements about it have not been evaluated by the U.S. Food and Drug Administration. Results vary with individual health status, consistency of use, and lifestyle. This page contains affiliate links — if you buy through them we may earn a small commission at no additional cost to you. Read our disclosure and our editorial policy.