NovuBrain+ Reviews: Caffeine-Free Bacopa and DHA Capsules

Seven named compounds in two capsules a day, no caffeine, no auto-ship and a 60-day guarantee. Here is what the label shows, and what the research behind each compound measured.

Try it with the 60-day guarantee →

It is rarely the big things. It is the word that sits just out of reach in the middle of a story at dinner, while everyone waits. It is the name of the actor, the street, the neighbour — there a moment ago, gone now, back at three in the morning when it no longer matters.

Then it is the afternoon. The same page read twice. The list you made so you would not forget, and then forgot to look at. Coffee helps for an hour and then leaves you exactly where you were, only more restless.

If you have tried to do something about it, you have probably already bought a bottle of something — bacopa, fish oil, a B-complex — taken it for a while, noticed nothing clear, and quietly stopped. And you have scrolled past enough pages promising a sharper brain in a week to distrust all of them.

So this page does the boring, useful thing. It reads the label. It tells you what is printed and what is not. It sets each compound against the human research that exists, and tells you honestly who this fits. With this particular bottle, the interesting part is how the pieces are arranged — and then you decide, which is the part nobody has been letting you do.

1. What Is NovuBrain+?

NovuBrain+ is a capsule supplement sold under the Nutraola name by Novustar Technologies LLC, a company based in Sheridan, Wyoming, through the maker’s own site. The maker states it is made in the USA in GMP-certified facilities, and that every batch is third-party lab tested for potency, purity and heavy metals.

The idea the maker builds the product around is what it calls neural throughput: the view that the word that will not come and the two o’clock slump are not simply age, but three things falling out of step — the signal between nerve cells, the membranes that carry it, and the fuel that runs them. NovuBrain+ is arranged in three matching groups. That is the maker’s framing, presented here as their explanation, and section four looks at what sits inside each group.

Two practical points stand out before any of that. The maker describes the formula as caffeine-free and stimulant-free, and it is sold as a one-time purchase, with no subscription and no auto-ship.

2. What Is In NovuBrain+?

We start here on every product, because it is the document you would read if you could hold the bottle. The sales page names seven compounds, and the front of the bottle names five of them: bacopa, phosphatidylserine, DHA omega-3, huperzine A and DMAE.

What you can check: the details the page does give. The bacopa is described as standardised for active bacosides rather than raw powder, which is the form the research uses. The phosphatidylserine is sunflower-derived and soy-free, which matters if you avoid soy. And the arithmetic of the bottle works out cleanly: 60 capsules at two a day is 30 days, which is what lets us publish a cost per day in section seven.

What the sales page does not print is an amount for any of the seven. None of that is evidence of a poor formula, and plenty of well-made products are sold this way. It is a plain statement of what you can and cannot check before you spend, and it matters most for the compounds whose research is tied to a specific amount.

3. What Does The Research Say About The Ingredients In NovuBrain+?

Four of the seven have a meaningful body of human research on memory or cognition. We take them in order of how much there is, and say plainly where it thins.

Bacopa monnieri — the best-defined

Bacopa has been through multiple randomised controlled trials and meta-analyses. A 2025 network meta-analysis of randomised trials in healthy older adults ranked a bacopa compound among the top plant substances studied for executive function and language function. The amount trials have commonly used is 300 mg a day, over eight to twelve weeks.

The picture is not unanimous. A 2025 trial in 101 adults aged 40 to 70 with self-reported memory and attention problems found no greater cognitive improvement than placebo at that same 300 mg over twelve weeks, though it did report effects on stress and fatigue. That is a real body of evidence with real disagreement in it, which is more than most ingredients in this aisle can claim.

Phosphatidylserine — modest, and studied in older adults

Phosphatidylserine is a phospholipid, one of the building blocks of cell membranes, and it is concentrated in the brain. A 2022 meta-analysis found it had a positive effect on memory in older adults with cognitive decline, across trials using 100 to 300 mg a day for six weeks to six months.

DHA omega-3 — mixed, and it depends on who was studied

DHA is the omega-3 fat found in especially high levels in the brain. The research on taking it for memory is genuinely mixed. The largest trial in healthy older adults, VITAL, gave 1 g of marine omega-3 a day — 840 mg of EPA and DHA combined — to people aged 60 and over for two to three years, and found no cognitive benefit over placebo. A 2024 meta-analysis of trials in older adults with mild cognitive impairment did find effects on memory and attention, and its authors rated that evidence as low certainty.

Huperzine A — the most pharmacologically active compound here

Huperzine A is an acetylcholinesterase inhibitor: it slows the enzyme that breaks down acetylcholine, a chemical messenger involved in memory. Reviews of the human trials report benefits on cognitive scales in Alzheimer’s populations, with reviewers consistently noting that the quality of the underlying trials was poor. A 2025 review describes it as a natural acetylcholinesterase inhibitor with neuroprotective effects under continuing study.

Two things follow from that, and both are useful. It is a real compound with real activity, not a filler. And it is the ingredient to name specifically when you speak to a prescriber.

L-glutamine, DMAE and vitamin B12

Vitamin B12 is essential for the nervous system, and low levels become more common with age. A 2021 meta-analysis of 16 trials found that, in people without advanced neurological disease, adding B12 did not measurably change cognitive function — so its value depends on whether you are low to begin with, which a simple blood test can show. DMAE and L-glutamine have human literature of varying depth, and for both the cognitive evidence in healthy adults is thin. And as with every finished formula sold this way, there is no published trial on this exact combination — the evidence above is evidence about ingredients.

4. How Is The NovuBrain+ Formula Designed?

Here is the part most readers miss, and it is the most useful thing on this page.

The seven compounds are not a random list. Four of them come in two pairs, and each pair has a logic you can check. Set the word “throughput” aside for a moment and look at what sits in each group.

The first group puts bacopa and huperzine A together, both chosen, in the maker’s description, for acetylcholine signalling — the messenger most closely tied to memory. For huperzine A that link is its established mechanism: it slows the enzyme that breaks acetylcholine down. For bacopa it is one of several mechanisms researchers have proposed. The second group pairs phosphatidylserine and DHA, and those two belong together for a structural reason: phosphatidylserine is one of the phospholipids brain-cell membranes are built from, and DHA is the omega-3 fat those membranes hold in especially high levels.

The third group — L-glutamine, DMAE and vitamin B12 — is the one with the thinnest cognitive research, and the maker presents it as support for the energy nerve cells use. Of the three, B12 is the one with a clear case, and mainly for people whose levels run low.

Which leaves a straightforward way to think about this bottle. If what you tried before was a single capsule of bacopa, or a fish oil, you tried one half of one pair. NovuBrain+ is built around the idea of taking both halves of two pairs in the same routine, and without caffeine. Whether that arrangement does more than its parts has not been tested as a formula — but it is a coherent design rather than a crowded one.

What the label does not let you do is check the amounts, and for bacopa and phosphatidylserine in particular, the published research is tied to specific ones. The figure below sets the amounts the trials used beside what this sales page states.

5. How Do You Take NovuBrain+, And When Would You Notice A Change?

The sales page gives a simple instruction: two capsules with breakfast, taken with food, every day. At 60 capsules a bottle, that is one bottle a month.

On timing, the ingredients answer for themselves. Bacopa’s trials ran eight to twelve weeks. Phosphatidylserine’s ran six weeks to six months. Nothing here acts on the day you take it, and change in this category is the kind you notice looking back rather than in the moment — easier to find a word in a conversation, a little more left in the afternoon.

This is where the guarantee becomes the practical point rather than a marketing line. The 60-day window covers roughly the first eight weeks, the short end of the bacopa trials. If you decide to try it, the most useful thing you can do is decide in advance what you will pay attention to — the missing words, the afternoon — and check in with yourself at week six, while the window is still open.

6. What Do Buyers Say About NovuBrain+?

Publicly posted feedback sits mostly on the manufacturer’s own page, which is not an independent source. We will not reproduce a review count or a rating, and this site publishes neither.

What can be said fairly: the themes the maker highlights are finding words more easily, fewer afternoon slumps and focus without jitter. Those are the right things to watch for yourself, and none of them requires a testimonial to judge — you are the one who will know.

7. How Much Does NovuBrain+ Cost, And Is There A Guarantee?

Prices are the manufacturer’s list prices at the time of writing and change without notice. We publish what a bottle costs. We do not publish savings claims and we do not reproduce countdown pricing.

Per-day cost uses the label: 60 capsules at two a day, so one bottle lasts 30 days. Every pack is a one-time charge.

The 60-day guarantee is the term the manufacturer publishes, and they handle it, not us. The sales page describes it as an empty-bottle guarantee: you can use the whole bottle, and if you do not feel a difference, you send back the empty within 60 days of purchase for a refund, with return shipping covered for US customers. The six-bottle pack also includes a digital guide from the maker.

And because it is a one-time purchase, there is nothing to cancel afterwards. If you want more, you order again.

8. Who Is NovuBrain+ For?

A question about you rather than about the bottle, so we will answer it that way.

This is likely a good fit if you have tried a single ingredient such as bacopa or fish oil and would rather take the related compounds together in one routine; if you want to stay away from caffeine, especially in the afternoon; if the idea of an auto-ship subscription has put you off supplements before; and if you can judge it over weeks rather than days.

Look elsewhere if you want to verify amounts against published trials before spending — this sales page does not allow it; if two capsules a day is more than you want to add; or if you take a prescription memory medicine, a beta-blocker, a calcium channel blocker or a blood thinner and have not yet raised huperzine A and DHA with your prescriber.

And the case where the answer is neither: if the forgetting has been getting worse month over month, or someone close to you has mentioned it, the next step is an appointment rather than a bottle. No supplement on this site prevents, treats or reverses any condition.

If that sounds like you, see NovuBrain+ →